Human Biobank

  • Biobanking LIMS system
  • Feces, blood (Serum, Plasma, RNA)
    • Matching PDX models for some patients
  • Data management: e-CRF, lifestyle & medical databases
Representation of Biofortis’s biobank



Microbiota monitoring & biological analysis for humans and mice

  • Targeted metagenomics & shotgun metasequencing
  • Analysis by dedicated bioinformatic pipeline
  • Companion diagnostic: e.g. inflammation, Oxidative stress, Immunity…

Example of studies

  • Cancer adjuvant therapy investigation (e.g. pre/probiotics)
  • Biomarker discovery
  • Drug discovery & treatment stratification

Contact the author

Francoise Le Vacon, Biofortis, Microbiome & Cancer


DR. FRANÇOISE LE VACON, PHD,
BIOFORTIS MERIEUX NUTRISCIENCES CSO



Biofortis - Microbiome & CancerInstitution: Biofortis Merieux NutriSciences
Address: 3 route de la Chatterie
44800 Saint-Herblain, France
Office: 33(0)2 40 20 57 99
Mobile: 33(0)6 08 05 29 32
E-mail: francoise.le.vacon@mxns.com


Brief Back Ground Information

Françoise Le Vacon is Chief Scientific Officer and co-founder of Biofortis Merieux NutriSciences.
She firstly obtained a Cellular and Molecular Biology Master at Rennes University, and then received her Ph.D. degree in Cell/Immunology at Nantes University.
She completed her post-doctoral training at Cochin Hospital and Pasteur Institute in Paris, Johns Hopkins Hospital and at the NIH in the US.
Dr. Le Vacon held research focusing on biomarker discovery in Oncology at Grenoble and on Microbiology over the last 20 years.
As Microbiome Research Program Leader, Françoise has set up a platform for the study of bacterial ecosystems for clinical and pre-clinical applications in nutrition and health.


National Award

2011: Knight of the Order of Merit for contribution in Science.


Publications

Le Bars P, Matamoros S, Montassier E, Le Vacon F, Potel G, Soueidan A, Jordana F, De La Cochétière MF. The oral cavity microbiota: between health, oral disease and cancers of the aerodigestive tract. Canadian Journal of Microbiology. [Epub ahead of print]

Touchefeu Y, Montassier E, Nieman K, Gastinne T, Potel G, Bruley des Varannes S, Le Vacon F, de La Cochetière MF. Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis - current evidence and potential clinical applications. Aliment Pharmacol Ther. 2014; 40(5): 409-21.

Montassier E, Batard E, Massart S, Gastinne T, Carton T, Caillon J, Le Fresne S, Caroff N, Hardouin JB, Moreau P, Potel G, Le Vacon F, de La Cochetière MF. 16S rRNA gene pyrosequencing reveals shift in patient faecal microbiota during high-dose chemotherapy as conditioning regimen for bone marrow transplantation. Microb Ecol. 2014;67(3):690-9.

Ekaza A, Kacou-N'douba A, Anne JCB, Le Vacon F, Montassier E, Potel G, de-La-Cochetiere MF. Infectious diarrheal diseases and the emergence of multiresistant strains: Focus on Côte d’Ivoire. Current Trends in Microbiology. 2013;8:75-88.

Ekaza E, N'Guessan RK, Kacou-N'Douba A, Aka N, Kouakou J, Le Vacon F, Altare F, Potel G, de-La-Cochetiere MF. Emergence in Western African countries of MDR-TB, focus on Côte d'Ivoire. Biomed Res Int. 2013;2013:426709.

Matamoros S, Gras-Leguen C, Le Vacon F, Potel G, de La Cochetiere MF. Development of intestinal microbiota in infants and its impact on health. Trends Microbiol. 2013;21(4):167-73.

Popova M, Molimard P, Courau S, Crociani J, Dufour C, Le Vacon F, Carton T. Beneficial effects of probiotics in upper respiratory tract infections and their mechanical actions to antagonize pathogens. J Appl Microbiol. 2012;113(6):1305-18.

de La Cochetière MF, Montassier E, Hardouin JB, Carton T, Le Vacon F, Durand T, Lalande V, Petit JC, Potel G, Beaugerie L. Human intestinal microbiota gene risk factors for antibiotic-associated diarrhea: perspectives for prevention. Risk factors for antibiotic-associated diarrhea. Microb Ecol. 2010;59(4):830-7.

Caillaux G, de La Cochetière MF, Carton T, Le Vacon F, Rozé JC, Potel G, Caillon J, Gras-Le Guen C.Application of denaturing high-performance liquid chromatography for intestinal microbiota analysis of newborns. J Perinat Med. 2010;38(3):339-41.